Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ACR | P10323 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11116148 | 0.88 | LMNA (0.57) | LMNATP53MAPTALPLRAB9A | |
| SCHEMBL11119913 | 0.86 | KDR (0.48) | LMNATP53MAPTALPLROCK2 | |
| SCHEMBL11114055 | 0.86 | KMT2A (0.49) | LMNAMAPTALPLRAB9AACR | |
| SCHEMBL11119372 | 0.82 | JAK2 (0.41) | LMNAMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL11121204 | 0.81 | KMT2A (0.50) | LMNAMAPTROCK2NPC1RAB9A | |
| SCHEMBL11120847 | 0.80 | LMNA (0.48) | LMNATP53MAPTNPC1RAB9A | |
| SCHEMBL11119990 | 0.78 | MAPT (0.49) | LMNATP53MAPTALDH1A1NPC1 | |
| SCHEMBL11121938 | 0.78 | KMT2A (0.55) | LMNATP53MAPTROCK2NPC1 | |
| SCHEMBL1376637 | 0.77 | LMNA (1.00) | LMNATP53MAPTALDH1A1GSK3A | |
| SCHEMBL11117029 | 0.77 | ALDH1A1 (0.54) | LMNAMAPTALDH1A1ALPLNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116853-A1 | Pyridazinones, processes for preparing them, therapeutical compositions containing these compounds and their use | BASF Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |