Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11120143 | 0.91 | CYP2C19 (0.57) | CYP2C19KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11114408 | 0.87 | MEN1 (0.55) | CYP2C19KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11111683 | 0.81 | MEN1 (0.57) | CYP2C19KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL696251 | 0.77 | AKR1C3 (0.67) | KMT2AMEN1MAPTHTT | |
| SCHEMBL5726893 | 0.77 | AKR1C3 (0.54) | KMT2AMEN1LMNAPOLB | |
| SCHEMBL8747120 | 0.75 | AKR1C3 (0.60) | — | |
| SCHEMBL3116411 | 0.75 | AKR1C3 (0.60) | — | |
| SCHEMBL3214214 | 0.74 | ALDH1A1 (0.71) | KMT2AMEN1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL2701748 | 0.74 | CHRNA7 (0.49) | KMT2AMEN1 | |
| SCHEMBL11117181 | 0.73 | CYP2C19 (0.67) | CYP2C19KMT2AMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034415-B1 | 1-(CYCLOHEXYL OR CYCLOHEXENYL)-4-ARYL-4-PIPERIDINECARBOXYLIC ACID DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-05-30 | — | — | EP | disclosed |
| US-4369184-A | ANTIHISTAMINES; HETEROCYCLIC NITRILES | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-18 | — | — | US | disclosed |