Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PKLR | P30613 | 1/20 | 0.45 |
| ▸ | OXTR | P30559 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1310091 | 0.83 | KMT2A (0.67) | MEN1KMT2AALDH1A1CYP2C19PKM | |
| SCHEMBL5470612 | 0.82 | KMT2A (0.62) | MEN1KMT2ACYP2C19LMNAPKM | |
| SCHEMBL11114824 | 0.81 | CYP2C19 (0.71) | MEN1KMT2AALDH1A1CYP2C19LMNA | |
| SCHEMBL11120143 | 0.80 | CYP2C19 (0.57) | MEN1KMT2AALDH1A1CYP2C19LMNA | |
| SCHEMBL14041008 | 0.78 | KMT2A (0.61) | KMT2ALMNA | |
| SCHEMBL11114408 | 0.77 | MEN1 (0.55) | MEN1KMT2AALDH1A1CYP2C19LMNA | |
| SCHEMBL5478315 | 0.76 | KMT2A (0.54) | MEN1KMT2ACYP2C19LMNAPKM | |
| SCHEMBL11602090 | 0.76 | OPRM1 (0.56) | MEN1KMT2AALDH1A1CYP2C19LMNA | |
| SCHEMBL4437271 | 0.76 | KDM1A (0.50) | KMT2AMAPK1 | |
| SCHEMBL11115677 | 0.75 | OXTR (0.55) | MEN1KMT2AALDH1A1CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034415-B1 | 1-(CYCLOHEXYL OR CYCLOHEXENYL)-4-ARYL-4-PIPERIDINECARBOXYLIC ACID DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-05-30 | — | — | EP | disclosed |
| US-4369184-A | ANTIHISTAMINES; HETEROCYCLIC NITRILES | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-18 | — | — | US | disclosed |
| EP-0034415-A1 | 1-(Cyclohexyl or cyclohexenyl)-4-aryl-4-piperidinecarboxylic acid derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-08-26 | — | — | EP | disclosed |