SCHEMBL11116079

SCHEMBL11116079

Nc1cc(Cl)ccc1C1[C]=CCc2ccccc21

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.34
CYP3A4 P08684 3/20 0.34
ALDH1A1 P00352 2/20 0.34
ALOX15 P16050 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
GAA P10253 2/20 0.33
CACNB4 O00305 1/20 0.33
CACNA1A O00555 1/20 0.33
CACNA1G O43497 1/20 0.33
CACNG3 O60359 1/20 0.33
CACNA1F O60840 1/20 0.33
CACNA1H O95180 1/20 0.33
CACNB3 P54284 1/20 0.33
CACNA2D1 P54289 1/20 0.33
CACNG7 P62955 1/20 0.33
CACNA1B Q00975 1/20 0.33
CACNA1D Q01668 1/20 0.33
CACNB1 Q02641 1/20 0.33
CACNG1 Q06432 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8418267 0.72 KDM1A (0.39) GAAHTR2AHTR2CHTR2BHRH3
SCHEMBL4019122 0.71 KDM1A (0.42) ALDH1A1CYP1A2CYP2C9CYP2C19ALOX12
SCHEMBL3669240 0.71 KDM4E (0.30) GAA
SCHEMBL3634708 0.70 PRCP (0.38) CYP3A4GAATP53ALOX12HPGD
SCHEMBL3389204 0.67 HTR2A (0.35) HTR2AHTR2C
SCHEMBL874497 0.66 HTR2A (0.34) CYP1A2CYP2C9CYP2C19HTR2AHTR2C
SCHEMBL3791259 0.63 TSHR (0.50) TSHRCYP3A4ALDH1A1ALOX15SMN1; SMN2
SCHEMBL458123 0.62 HTR2A (0.34) HTR2AHTR2C
SCHEMBL458495 0.62 HTR2A (0.35) ALDH1A1HTR2AHTR2CHTR2BMAPT
SCHEMBL4307808 0.62 HTR2A (0.34) HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0121495-A1 Monoazo dyestuffs, their preparation and their use CIBA-GEIGY AG (CH) 1984-10-10 EP disclosed