Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.55 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.51 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.51 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15966134 | 0.95 | SIGMAR1 (0.60) | SIGMAR1TMEM97CARM1PRMT6PRMT8 | |
| SCHEMBL15966141 | 0.94 | SIGMAR1 (0.58) | SIGMAR1TMEM97CARM1PRMT6PRMT8 | |
| SCHEMBL15966137 | 0.94 | SIGMAR1 (0.58) | SIGMAR1TMEM97CARM1PRMT6PRMT8 | |
| SCHEMBL15966136 | 0.94 | SIGMAR1 (0.58) | SIGMAR1TMEM97CARM1PRMT6PRMT8 | |
| SCHEMBL15966135 | 0.94 | SIGMAR1 (0.58) | SIGMAR1TMEM97CARM1PRMT6PRMT8 | |
| SCHEMBL11117996 | 0.90 | CARM1 (0.55) | SIGMAR1TMEM97CARM1PRMT6PRMT8 | |
| SCHEMBL11117998 | 0.84 | CARM1 (0.56) | SIGMAR1TMEM97CARM1PRMT6PRMT8 | |
| SCHEMBL13991801 | 0.84 | CARM1 (0.56) | SIGMAR1TMEM97CARM1PRMT6PRMT8 | |
| SCHEMBL1638713 | 0.82 | SIGMAR1 (0.67) | SIGMAR1TMEM97CARM1PRMT6PRMT8 | |
| SCHEMBL16081555 | 0.81 | CARM1 (0.53) | SIGMAR1TMEM97CARM1PRMT6PRMT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0041757-B1 | ETHYLENDIAMINE DERIVATIVES, PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND INTERMEDIATES FOR THEIR PREPARATION | Simes S.p.A. (IT) | 1984-11-07 | — | — | EP | disclosed |