SCHEMBL11117747

SCHEMBL11117747

Cc1c(O)cc(C(C)(C)C)cc1CN(C)C

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 5/20 0.68
ALOX15 P16050 3/20 0.53
MAPK1 P28482 1/20 0.53
HTT P42858 1/20 0.53
ALDH1A1 P00352 4/20 0.48
GAA P10253 2/20 0.48
TDP1 Q9NUW8 2/20 0.48
KDM4E B2RXH2 1/20 0.48
MEN1 O00255 1/20 0.48
POLB P06746 1/20 0.48
MAPT P10636 1/20 0.48
THRB P10828 1/20 0.48
G6PD P11413 1/20 0.48
PABPC1 P11940 1/20 0.48
KMT2A Q03164 1/20 0.48
HKDC1 Q2TB90 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
CYP1A2 P05177 5/20 0.47
CYP2D6 P10635 8/20 0.46
CYP2C9 P11712 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13234914 0.84 CYP2C19 (0.82) CYP2C19ALOX15MAPK1HTTALDH1A1
SCHEMBL7117673 0.81 CYP2C19 (1.00) CYP2C19ALOX15MAPK1HTTALDH1A1
SCHEMBL10874465 0.78 CYP2C19 (0.67) CYP2C19ALOX15MAPK1HTTALDH1A1
SCHEMBL9744092 0.76 GABRA1 (0.55) CYP2C19ALOX15MAPK1HTTALDH1A1
SCHEMBL6057546 0.75 CYP2C19 (0.79) CYP2C19ALOX15MAPK1HTTALDH1A1
SCHEMBL11412672 0.74 GABRA1 (0.52) CYP2C19ALOX15MAPK1ALDH1A1GAA
SCHEMBL6673984 0.74 TYR (0.43) CYP2C19ALOX15MAPK1HTTALDH1A1
SCHEMBL12724796 0.72 CYP2C19 (0.67) CYP2C19ALOX15MAPK1HTTALDH1A1
SCHEMBL5072462 0.71 ALDH1A1 (0.58) CYP2C19ALOX15MAPK1HTTALDH1A1
Hydrochloric Acid SCHEMBL10641748 0.71 CYP2C19 (0.66) CYP2C19ALOX15MAPK1HTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0116712-A1 Synthesis of hindered phenols ETHYL CORPORATION (US) 1984-08-29 EP disclosed