Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8779979 | 0.83 | ALDH1A1 (0.34) | TSHRTHRBALDH1A1 | |
| SCHEMBL29022495 | 0.75 | ALDH1A1 (0.37) | TSHRTHRBALDH1A1 | |
| Bromide SCHEMBL8779975 | 0.73 | TSHR (0.42) | TSHRTHRB | |
| SCHEMBL5700059 | 0.73 | ALDH1A1 (0.38) | TSHRTHRBALDH1A1 | |
| SCHEMBL27472271 | 0.72 | TSHR (0.42) | TSHRTHRBALDH1A1 | |
| Bromide SCHEMBL7914479 | 0.72 | TSHR (0.45) | TSHRTHRB | |
| Hydrochloric Acid SCHEMBL2992246 | 0.72 | ALDH1A1 (0.37) | TSHRTHRBALDH1A1 | |
| SCHEMBL9347696 | 0.71 | TSHR (0.41) | TSHRTHRBALDH1A1 | |
| SCHEMBL29055152 | 0.71 | TSHR (0.41) | TSHRTHRBALDH1A1 | |
| SCHEMBL28994779 | 0.69 | TSHR (0.40) | TSHRTHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460567-A | HAIR TREATMENT, ACRYLAMIDE COPOLYMERS | CIBA-GEIGY CORPORATION (US) | 1984-07-17 | — | — | US | disclosed |
| US-4460569-A | SULFOSUCCINATE ANIONIC SURFACTANT | CIBA-GEIGY CORPORATION (US) | 1984-07-17 | — | — | US | disclosed |
| US-4460570-A | HAIR CONDITIONING, ACRYLAMIDE COPOLYMERS | CIBA-GEIGY CORPORATION (US) | 1984-07-17 | — | — | US | disclosed |
| US-4460568-A | Quaternary, copolymeric, high molecular weight ammonium salts based on acrylic compounds, their preparation, and their use in cosmetics | CIBA-GEIGY CORPORATION (US) | 1984-07-17 | — | — | US | disclosed |
| US-4454114-A | Quaternary, copolymeric, high molecular weight ammonium salts based on acrylic compounds, and their use in cosmetics for the hair | CIBA-GEIGY CORPORATION (US) | 1984-06-12 | — | — | US | disclosed |
| US-4440744-A | Quaternary, copolymeric, high molecular weight ammonium salts based on acrylic compounds, and their use in cosmetics | CIBA-GEIGY CORPORATION (US) | 1984-04-03 | — | — | US | disclosed |
| US-4419344-A | Quaternary, copolymeric, high molecular weight ammonium salts based on acrylic compounds, their preparation, and their use in cosmetics | CIBA-GEIGY CORPORATION (US) | 1983-12-06 | — | — | US | disclosed |
| US-4393886-A | Mixtures of quaternary, polymeric, high molecular weight ammonium salts, which are based on acrylic compounds, and surfactants, their preparation, and their use in cosmetics | CIBA-GEIGY CORPORATION (US) | 1983-07-19 | — | — | US | disclosed |