Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7914479 | 0.98 | TSHR (0.45) | TSHRMEN1MAPTKMT2AATM | |
| Hydrochloric Acid SCHEMBL8779979 | 0.79 | ALDH1A1 (0.34) | TSHRTHRB | |
| SCHEMBL5700059 | 0.77 | ALDH1A1 (0.38) | TSHRTHRB | |
| Hydrochloric Acid SCHEMBL2992246 | 0.75 | ALDH1A1 (0.37) | TSHRTHRB | |
| Hydrochloric Acid SCHEMBL10684429 | 0.75 | TSHR (0.40) | TSHRCES2THRB | |
| Bromide SCHEMBL11117782 | 0.73 | TSHR (0.35) | TSHRTHRB | |
| Bromide SCHEMBL6416514 | 0.72 | CES2 (0.39) | TSHRMEN1MAPTKMT2AATM | |
| Bromide SCHEMBL9510259 | 0.72 | CES2 (0.39) | TSHRMEN1MAPTKMT2AATM | |
| SCHEMBL372522 | 0.70 | CES2 (0.39) | TSHRMEN1MAPTKMT2AATM | |
| SCHEMBL5856021 | 0.70 | TSHR (0.50) | TSHRMEN1MAPTKMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525751-B1 | Process for the preparation of an aqueous dispersion of water-soluble cationic polymer | HYMO CORP (JP) | 1997-06-25 | — | — | EP | disclosed |
| US-5587415-A | FLOCCULANT, PAPER CHEMISTRY | HYMO CORPORATION (JP) | 1996-12-24 | — | — | US | disclosed |
| EP-0525751-A1 | Process for the preparation of dispersion of water-soluble cationic polymer | HYMO CORPORATION (JP) | 1993-02-03 | — | — | EP | disclosed |