Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.83 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.73 |
| ▸ | MAOB | P27338 | 6/20 | 0.71 |
| ▸ | MAOA | P21397 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | F2 | P00734 | 1/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.57 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.57 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.57 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.57 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1369316 | 0.85 | NR4A2 (1.00) | NR4A2MAOBMAOANPC1RAB9A | |
| SCHEMBL12339549 | 0.83 | PARP10 (0.83) | PARP10MAOBNPC1RAB9AALDH1A1 | |
| SCHEMBL11119945 | 0.83 | NR4A2 (0.64) | PARP10NR4A2MAOBMAOANPC1 | |
| SCHEMBL9778577 | 0.83 | MAOB (1.00) | NR4A2MAOBMAOANPC1RAB9A | |
| SCHEMBL5999764 | 0.83 | PARP10 (0.87) | PARP10NR4A2MAOBNPC1RAB9A | |
| SCHEMBL119689 | 0.83 | PARP10 (1.00) | PARP10NR4A2MAOB | |
| SCHEMBL9808170 | 0.82 | NR4A2 (0.71) | PARP10NR4A2MAOBMAOANPC1 | |
| SCHEMBL11292762 | 0.82 | NR4A2 (0.71) | PARP10NR4A2MAOBMAOANPC1 | |
| SCHEMBL26106172 | 0.82 | NR4A2 (0.71) | PARP10NR4A2MAOBMAOANPC1 | |
| SCHEMBL10991891 | 0.82 | MAOB (0.80) | NR4A2MAOBMAOANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028305-B1 | DIARYL COMPOUNDS AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-02-01 | — | — | EP | claimed |
| EP-0028305-A1 | Diaryl compounds and pharmaceutical formulations containing them | THE WELLCOME FOUNDATION LIMITED (GB) | 1981-05-13 | — | — | EP | claimed |
| EP-0028305-B1 | DIARYL COMPOUNDS AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-02-01 | — | — | EP | disclosed |
| EP-0028305-A1 | Diaryl compounds and pharmaceutical formulations containing them | THE WELLCOME FOUNDATION LIMITED (GB) | 1981-05-13 | — | — | EP | disclosed |