Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 5/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.62 |
| ▸ | F2 | P00734 | 2/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.57 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.57 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.57 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.57 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.57 |
| ▸ | DHFR | P00374 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CCR6 | P51684 | 1/20 | 0.54 |
| ▸ | UBE2N | P61088 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558672 | 0.83 | NPC1 (0.64) | MAOBF2APPPARP10PRSS1 | |
| SCHEMBL11117974 | 0.83 | PARP10 (0.83) | NR4A2MAOBMAOAF2APP | |
| SCHEMBL6890765 | 0.83 | PARP10 (0.70) | NR4A2MAOBMAOAF2PARP10 | |
| SCHEMBL10991891 | 0.82 | MAOB (0.80) | NR4A2MAOBMAOAAPPDHFR | |
| SCHEMBL16697339 | 0.81 | NR4A2 (0.60) | NR4A2MAOBMAOAF2APP | |
| SCHEMBL16697343 | 0.81 | NR4A2 (0.60) | NR4A2MAOBMAOAF2APP | |
| SCHEMBL11600066 | 0.78 | MAOB (0.69) | NR4A2MAOBMAOAAPPDHFR | |
| SCHEMBL12127490 | 0.78 | MAOA (0.54) | MAOBMAOAF2PARP10ST14 | |
| SCHEMBL3624903 | 0.78 | MAOB (0.69) | NR4A2MAOBMAOAAPPDHFR | |
| SCHEMBL1369316 | 0.78 | NR4A2 (1.00) | NR4A2MAOBMAOANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028305-B1 | DIARYL COMPOUNDS AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-02-01 | — | — | EP | disclosed |
| EP-0028305-A1 | Diaryl compounds and pharmaceutical formulations containing them | THE WELLCOME FOUNDATION LIMITED (GB) | 1981-05-13 | — | — | EP | disclosed |