Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 17/20 | 0.58 |
| ▸ | HTR1A | P08908 | 4/20 | 0.58 |
| ▸ | DRD2 | P14416 | 4/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11116297 | 0.83 | POLB (0.53) | ABCB1TAAR1 | |
| SCHEMBL30080050 | 0.79 | TAAR1 (0.77) | ABCB1HTR1ADRD2ABCG2TAAR1 | |
| SCHEMBL723511 | 0.79 | TAAR1 (0.77) | ABCB1HTR1ADRD2ABCG2TAAR1 | |
| SCHEMBL2507390 | 0.77 | FFAR1 (0.48) | HTR1ADRD2 | |
| SCHEMBL4060273 | 0.77 | TAAR1 (0.69) | ABCB1HTR1ADRD2ABCG2TAAR1 | |
| SCHEMBL30416326 | 0.77 | ABCB1 (0.62) | ABCB1HTR1ADRD2ABCG2TAAR1 | |
| SCHEMBL4189173 | 0.77 | ABCB1 (0.62) | ABCB1HTR1ADRD2ABCG2TAAR1 | |
| SCHEMBL22050342 | 0.77 | ABCB1 (0.62) | ABCB1HTR1ADRD2ABCG2TAAR1 | |
| SCHEMBL11116346 | 0.77 | BACE1 (0.50) | TAAR1 | |
| SCHEMBL5101839 | 0.77 | ABCB1 (0.62) | ABCB1HTR1ADRD2ABCG2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0115690-A1 | Dibenzocycloheptenylidenes | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-08-15 | — | — | EP | disclosed |