Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11121526 | 0.93 | KDR (0.47) | KDRJAK2NTRK1RETPDGFRB | |
| SCHEMBL11121541 | 0.88 | JAK2 (0.50) | KDRJAK2NTRK1RETPDGFRB | |
| SCHEMBL11119990 | 0.88 | MAPT (0.49) | KDRJAK2NTRK1RETPDGFRB | |
| SCHEMBL11121326 | 0.88 | JAK2 (0.47) | KDRJAK2NTRK1RETPDGFRB | |
| SCHEMBL11117029 | 0.85 | ALDH1A1 (0.54) | KDRJAK2NTRK1RETPDGFRB | |
| SCHEMBL11121204 | 0.85 | KMT2A (0.50) | KDRJAK2NTRK1RETPDGFRB | |
| SCHEMBL11120847 | 0.84 | LMNA (0.48) | KDRJAK2NTRK1RETPDGFRB | |
| SCHEMBL11119210 | 0.84 | CYP1A2 (0.50) | KDRJAK2NTRK1RETPDGFRB | |
| SCHEMBL11115726 | 0.84 | JAK2 (0.45) | KDRJAK2NTRK1RETPDGFRB | |
| SCHEMBL11119048 | 0.83 | KDR (0.46) | KDRJAK2NTRK1RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116853-A1 | Pyridazinones, processes for preparing them, therapeutical compositions containing these compounds and their use | BASF Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |