Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11124682 | 1.00 | PARP1 (0.52) | PARP1RECQLPDE4APDE4BPDE4C | |
| SCHEMBL21901287 | 1.00 | PARP1 (0.52) | PARP1RECQLPDE4APDE4BPDE4C | |
| SCHEMBL17268849 | 0.80 | GABRA1 (0.51) | PARP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11117845 | 0.79 | PDE4A (0.65) | PARP1RECQLPDE4APDE4BPDE4C | |
| SCHEMBL11290195 | 0.79 | PDE4A (0.65) | PARP1RECQLPDE4APDE4BPDE4C | |
| SCHEMBL11117847 | 0.79 | PDE4A (0.65) | PARP1RECQLPDE4APDE4BPDE4C | |
| SCHEMBL11085889 | 0.79 | RECQL (0.62) | PARP1RECQLPDE4APDE4BPDE4C | |
| SCHEMBL11083594 | 0.79 | PARP1 (0.52) | PARP1RECQLPDE4APDE4BPDE4C | |
| SCHEMBL3958624 | 0.79 | RECQL (0.49) | RECQLPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11072261 | 0.79 | PARP1 (0.52) | PARP1RECQLGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129407-A2 | Improvements in and relating to (3-aryl-5-isothiazolyl)ureas | ELI LILLY AND COMPANY (US) | 1984-12-27 | — | — | EP | disclosed |