SCHEMBL111279

SCHEMBL111279

O=C(O)c1ccc(Cl)cc1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 1.00
CASP1 P29466 1/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
ALDH1A1 P00352 4/20 0.68
TP53 P04637 1/20 0.68
SRD5A2 P31213 1/20 0.63
MAPK1 P28482 1/20 0.61
HIF1A Q16665 1/20 0.61
CA1 P00915 1/20 0.59
CA2 P00918 1/20 0.59
KDM4E B2RXH2 1/20 0.59
MAPT P10636 1/20 0.59
ERCC5 P28715 1/20 0.58
FEN1 P39748 1/20 0.58
PPARG P37231 1/20 0.54
PPARA Q07869 1/20 0.54
AKR1C4 P17516 1/20 0.54
AKR1C3 P42330 1/20 0.54
AKR1C2 P52895 1/20 0.54
AKR1C1 Q04828 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28852873 0.98 TSHR (0.95) TSHRCASP1SMN1; SMN2ALDH1A1TP53
SCHEMBL6233608 0.98 TSHR (0.95) TSHRCASP1SMN1; SMN2ALDH1A1TP53
SCHEMBL1303476 0.98 TSHR (0.95) TSHRCASP1SMN1; SMN2ALDH1A1TP53
Hydrochloric Acid SCHEMBL9651764 0.98 TSHR (0.95) TSHRCASP1SMN1; SMN2ALDH1A1TP53
Ammonia Solution, Strong SCHEMBL4373474 0.98 TSHR (0.95) TSHRCASP1SMN1; SMN2ALDH1A1TP53
SCHEMBL1151260 0.98 TSHR (0.95) TSHRCASP1SMN1; SMN2ALDH1A1TP53
Thioglycolic Acid SCHEMBL8860110 0.88 SMN1; SMN2 (0.78) TSHRCASP1SMN1; SMN2ALDH1A1TP53
Acetonitrile SCHEMBL28488651 0.88 TSHR (0.78) TSHRCASP1SMN1; SMN2ALDH1A1TP53
Benzoic Acid SCHEMBL8021112 0.88 TSHR (0.78) TSHRCASP1SMN1; SMN2ALDH1A1TP53
SCHEMBL8860105 0.87 SMN1; SMN2 (0.75) TSHRCASP1SMN1; SMN2ALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2886 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 EP claimed
CN-120059297-A Crosslinking agent for rubber and preparation method thereof 广西产研院新型功能材料研究所有限公司 2025-05-30 CN claimed
CN-119707655-A 3-Hydroxy-2, 4-dichloro acetophenone prepared by one-pot method and preparation method thereof 江西永通科技股份有限公司 2025-03-28 CN claimed
CN-119504408-A Cyanate resin curing agent, single-component latent cyanate resin and preparation method 北京化工大学 2025-02-25 CN claimed
WO-2024167565-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS PURDUE RESEARCH FOUNDATION (US) 2024-08-15 WO claimed
CN-118290370-A Production process and purification method of furosemide 台山市新宁制药有限公司 2024-07-05 CN claimed
CN-118184679-A Photothermal agent and preparation method thereof, photothermal nanoparticle and preparation method thereof, insulating material and self-repairing method of insulating material 中国石油天然气股份有限公司 2024-06-14 CN claimed
CN-117603604-B Preparation method of printing gloss oil with amino-terminated hyperbranched self-assembled polyamide as main component 江苏众立生包装科技有限公司 2024-05-24 CN claimed
CN-115850123-B Preparation method of 2, 4-dichloroaniline/hydrazine 山东潍坊润丰化工股份有限公司 2024-04-19 CN claimed
CN-117816164-A Composite catalyst and application thereof in synthesis of substituted benzimidazole derivative 广东省科学院化工研究所 2024-04-05 CN claimed
EP-0172147-A2 Amide derivatives of 2-(p-aminobenzyl)-butyric acid and esters thereof having hypolipidemizing activity Medosan Industrie Biochimiche Riunite S.r.l. (IT) 1986-02-19 EP claimed
EP-0170164-A2 Silver halide color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1986-02-05 EP claimed
US-4542234-A Process for the separation of (S,S) diastereoisomers USV PHARMACEUTICAL CORP. (US) 1985-09-17 US claimed
US-4302521-A TRANSPORT PHASE OF A P-TYPE ORGANIC SEMICONDUCTOR, POLYVINYLCARBAZOLE, A LEWIS AND A BRONSTED ACID; CHARGE TRANSFER COMPOUNDS KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1981-11-24 US claimed
US-4243740-A Light sensitive compositions of polymethyl isopropenyl ketone TOKYO OHKA KOGYO KABUSHIKI KAISHA (JP) 1981-01-06 US claimed
US-4159208-A REACTING ALKALI METAL SALT OF AN AROMATIC CARBOXYLIC ACID AND A METAL SALT IN THE PRESENCE OF CLAY AND ALUMINUM COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1979-06-26 US claimed
US-4150206-A SYNERGISTIC CATALYSTS S.A. PRB (BE) 1979-04-17 US claimed
US-4063889-A Halosolvent dyeing process for polyester with cationic dyes having sulfosuccinate anions E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-12-20 US claimed
US-RE29226-E Preparation of carboxylate and sulfonate salts of 1-cis-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo(3.3.1.13,7)decane-II THE DOW CHEMICAL COMPANY (US) 1977-05-17 US claimed
US-3996188-A AROMATIC ACIDS DOW CORNING CORPORATION (US) 1976-12-07 US claimed