Acetonitrile

Acetonitrile

SCHEMBL28488651

CC#N.O=C(O)c1ccc(Cl)cc1Cl

nearest known ligand 0.78

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.78
CASP1 P29466 1/20 0.78
SMN1; SMN2 Q16637 1/20 0.78
ALDH1A1 P00352 2/20 0.55
TP53 P04637 1/20 0.55
GABRA1 P14867 6/20 0.54
GABRG2 P18507 6/20 0.54
GABRB3 P28472 6/20 0.54
GABRB2 P47870 4/20 0.54
GABRB1 P18505 2/20 0.54
SRD5A2 P31213 1/20 0.53
PPARG P37231 1/20 0.50
PPARA Q07869 1/20 0.50
MAPK1 P28482 1/20 0.50
HIF1A Q16665 1/20 0.50
ERCC5 P28715 1/20 0.49
FEN1 P39748 1/20 0.49
KDM4E B2RXH2 1/20 0.49
MAPT P10636 1/20 0.49
CA1 P00915 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL111279 0.88 TSHR (1.00) TSHRCASP1SMN1; SMN2ALDH1A1TP53
SCHEMBL1151260 0.86 TSHR (0.95) TSHRCASP1SMN1; SMN2ALDH1A1TP53
SCHEMBL6233608 0.86 TSHR (0.95) TSHRCASP1SMN1; SMN2ALDH1A1TP53
Ammonia Solution, Strong SCHEMBL4373474 0.86 TSHR (0.95) TSHRCASP1SMN1; SMN2ALDH1A1TP53
SCHEMBL1303476 0.86 TSHR (0.95) TSHRCASP1SMN1; SMN2ALDH1A1TP53
Hydrochloric Acid SCHEMBL9651764 0.86 TSHR (0.95) TSHRCASP1SMN1; SMN2ALDH1A1TP53
SCHEMBL28852873 0.86 TSHR (0.95) TSHRCASP1SMN1; SMN2ALDH1A1TP53
Thioglycolic Acid SCHEMBL8860110 0.78 SMN1; SMN2 (0.78) TSHRCASP1SMN1; SMN2ALDH1A1TP53
Benzoic Acid SCHEMBL8021112 0.78 TSHR (0.78) TSHRCASP1SMN1; SMN2ALDH1A1TP53
SCHEMBL5666673 0.77 TSHR (0.59) TSHRCASP1SMN1; SMN2ALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107831225-B Application of stearic acid/palmitic acid combination as aGVHD disease diagnosis marker 苏州大学附属第一医院 2021-08-10 CN disclosed
CN-107917971-B Application of myristic acid and glycerol composition in evaluating curative effect of chronic myelogenous leukemia TKI 苏州大学附属第一医院 2020-11-24 CN disclosed