Naphthoquinone

Naphthoquinone

SCHEMBL11129114

O=C1C=CC(=O)c2ccccc21.O=C1c2ccccc2C(=O)c2c1ccc1ccccc21

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 1/20 0.66
MEN1 O00255 5/20 0.56
KMT2A Q03164 5/20 0.56
ALDH1A1 P00352 5/20 0.56
MAPT P10636 3/20 0.56
SMN1; SMN2 Q16637 3/20 0.56
RAB9A P51151 2/20 0.56
MAPK1 P28482 4/20 0.56
HPGD P15428 2/20 0.56
ALOX12 P18054 2/20 0.56
CYP1A2 P05177 2/20 0.56
CYP2D6 P10635 2/20 0.56
CYP2C9 P11712 2/20 0.56
CYP2C19 P33261 2/20 0.56
HIF1A Q16665 2/20 0.56
LMNA P02545 2/20 0.56
USP2 O75604 1/20 0.56
TP53 P04637 1/20 0.56
CES1 P23141 1/20 0.53
MAOA P21397 4/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29612224 0.91 DNMT1 (0.78) DNMT1MEN1KMT2AALDH1A1MAPT
SCHEMBL29411157 0.91 DNMT1 (0.78) DNMT1MEN1KMT2AALDH1A1MAPT
SCHEMBL183078 0.91 DNMT1 (0.78) DNMT1MEN1KMT2AALDH1A1MAPT
SCHEMBL29358121 0.91 DNMT1 (0.78) DNMT1MEN1KMT2AALDH1A1MAPT
SCHEMBL7122517 0.85 DNMT1 (0.73) DNMT1MEN1KMT2AALDH1A1MAPT
SCHEMBL3922177 0.83 DNMT1 (0.71) DNMT1MEN1KMT2AALDH1A1MAPT
SCHEMBL29466071 0.83 DNMT1 (0.71) DNMT1MEN1KMT2AALDH1A1MAPT
SCHEMBL2175783 0.83 DNMT1 (0.92) DNMT1MEN1KMT2AALDH1A1MAPT
SCHEMBL29440308 0.83 DNMT1 (0.92) DNMT1MEN1KMT2AALDH1A1MAPT
SCHEMBL30375875 0.83 DNMT1 (0.92) DNMT1MEN1KMT2AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4486519-A HIGH PHOTOSENSITYIVITY AND FLEXIBILITY RICOH COMPANY, LTD. (JP) 1984-12-04 US disclosed
US-4426327-A PIGMENTS IN ELECTROGRAPHY RICOH CO., LTD. (JP) 1984-01-17 US disclosed
US-4327168-A Electrophotographic element containing disazo pigment charge generating material RICOH CO., LTD. (JP) 1982-04-27 US disclosed
US-4314015-A Electrophotographic sensitive materials containing disazo compounds RICOH CO., LTD. (JP) 1982-02-02 US disclosed
US-4299896-A Electrophotographic sensitive materials containing a disazo pigment RICOH CO., LTD. (JP) 1981-11-10 US disclosed
US-4293492-A PHOTOCONDUCTIVITY, ELECTROGRAPHY, PIGMENT RICOH CO., LTD. (JP) 1981-10-06 US disclosed
US-4293628-A Electrophotographic elements containing disazo compounds RICOH CO., LTD. (JP) 1981-10-06 US disclosed
US-4279981-A Electrophotographic elements containing trisazo compounds RICOH COMPANY, LTD. (JP) 1981-07-21 US disclosed
US-4272598-A STYRYL DYES RICOH CO., LTD. (JP) 1981-06-09 US disclosed
US-4268596-A Electrophotographic element having 1,4-bis(azostyryl)-2,5 dimethoxy benzene compounds as photoconductors RICOH COMPANY, LTD. (JP) 1981-05-19 US disclosed
US-4260672-A Electrophotographic sensitive element having a photoconductive disazo pigment RICOH COMPANY, LTD. (JP) 1981-04-07 US disclosed
US-4251613-A LAMINATE OF CONDUCTIVE SUPPORT AND PHOTOSENSITIVE LAYER RICOH COMPANY, LTD. (JP) 1981-02-17 US disclosed
US-4251614-A CARBAZOLE DERIVATIVES RICOH COMPANY, LTD. (JP) 1981-02-17 US disclosed
US-4247614-A Electrophotographic element containing a disazo pigment RICOH CO., LTD. (JP) 1981-01-27 US disclosed
US-4242260-A ELECTROGRAPHY; PHOTOCONDUCTIVITY RICOH COMPANY, LTD. (JP) 1980-12-30 US disclosed
US-4229511-A Electrophotography with uniform exposure for residual potential RICOH COMPANY, LTD. (JP) 1980-10-21 US disclosed