Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 4/20 | 0.34 |
| ▸ | FNTB | P49356 | 4/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11124423 | 0.94 | LMNA (0.42) | LMNASMN1; SMN2PPIDPTPN1MME | |
| SCHEMBL10972441 | 0.91 | LMNA (0.43) | LMNASMN1; SMN2PSMB8PSMB5KMT2A | |
| SCHEMBL11455957 | 0.91 | PTPN1 (0.44) | LMNAPTPN1FNTAFNTBPGGT1B | |
| Ambamustine SCHEMBL62822 | 0.90 | LMNA (0.41) | HTTLMNASMN1; SMN2PPIDPTPN1 | |
| Ambamustine SCHEMBL1419557 | 0.89 | LMNA (0.40) | HTTLMNASMN1; SMN2PPIDPTPN1 | |
| SCHEMBL11446573 | 0.89 | LMNA (0.46) | LMNAPTPN1MMEANPEPFNTA | |
| SCHEMBL11127008 | 0.82 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2PPIDMMEANPEP | |
| SCHEMBL11125479 | 0.82 | LMNA (0.51) | LMNASMN1; SMN2PTPN1MMEKMT2A | |
| Hydrochloric Acid SCHEMBL11124542 | 0.81 | SMN1; SMN2 (0.45) | LMNASMN1; SMN2PPIDMMEANPEP | |
| SCHEMBL10653336 | 0.80 | FNTA (0.49) | LMNASMN1; SMN2PTPN1FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0056565-B1 | DERIVATIVES OF DI(-2-CHLOROETHYL) AMINOPHENYL ALANINE WITH ANTITUMOUR ACTIVITY | PROTER S.p.A. (IT) | 1984-12-05 | — | — | EP | disclosed |
| US-4216208-A | N-Acyl derivatives of glucosamines having antitumor chemotherapeutic activity | PROTER S.P.A. (IT) | 1980-08-05 | — | — | US | disclosed |