Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11129156 | 0.91 | HTT (0.39) | LMNASMN1; SMN2KMT2APSMB8PSMB5 | |
| SCHEMBL11125479 | 0.88 | LMNA (0.51) | LMNASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL10653540 | 0.88 | LMNA (0.47) | LMNASMN1; SMN2TP53NOS2KMT2A | |
| SCHEMBL6838403 | 0.88 | LMNA (0.47) | LMNASMN1; SMN2TP53NOS2KMT2A | |
| SCHEMBL11124423 | 0.86 | LMNA (0.42) | LMNASMN1; SMN2 | |
| SCHEMBL6667620 | 0.85 | PSMB5 (0.44) | LMNASMN1; SMN2PSMB8PSMB5CTSB | |
| SCHEMBL11122837 | 0.84 | LMNA (0.42) | LMNASMN1; SMN2TP53NOS2KMT2A | |
| SCHEMBL11455957 | 0.82 | PTPN1 (0.44) | LMNAKMT2A | |
| SCHEMBL11446573 | 0.82 | LMNA (0.46) | LMNAKMT2AALDH1A1 | |
| SCHEMBL6666650 | 0.81 | PSMB5 (0.40) | LMNASMN1; SMN2PSMB8PSMB5CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4508710-A | DICHLORODIETHYLAMINOPHENYLALANINE, PARAFLUOROPHENYLALANINE AND METHIONINE | PROTER S.P.A. (IT) | 1985-04-02 | — | — | US | disclosed |
| EP-0056565-B1 | DERIVATIVES OF DI(-2-CHLOROETHYL) AMINOPHENYL ALANINE WITH ANTITUMOUR ACTIVITY | PROTER S.p.A. (IT) | 1984-12-05 | — | — | EP | disclosed |