Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.65 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.41 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.39 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | THRB | P10828 | 2/20 | 0.67 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | APEX1 | P27695 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11131965 | 0.98 | POLB (0.69) | POLBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL6266901 | 0.80 | POLB (0.67) | POLBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL111109 | 0.80 | PRKCI (1.00) | POLBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL29565648 | 0.80 | PRKCI (1.00) | POLBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL11269728 | 0.80 | POLB (0.67) | POLBKDM4EMEN1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL1998660 | 0.78 | ACHE (1.00) | POLBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL2486453 | 0.78 | PRKCI (0.65) | POLBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL5619685 | 0.78 | PRKCI (0.65) | POLBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL13339103 | 0.78 | PRKCI (0.65) | POLBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL2486451 | 0.78 | PRKCI (0.65) | POLBKDM4EMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4383023-A | USING A POSITIVE- OR NEGATIVE-CHARGED TANNING DEVELOPER AND OPPOSITELY-CHARGED MORDANT; GELATIN-SILVER HALIDE PHOTOGRAPHIC FILMS; | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-05-10 | — | — | US | disclosed |