Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.73 |
| ▸ | THRA | P10827 | 2/20 | 0.65 |
| ▸ | THRB | P10828 | 2/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | FDPS | P14324 | 3/20 | 0.57 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL11134632 | 1.00 | SIGMAR1 (0.73) | SIGMAR1THRATHRBKCNH2FDPS | |
| Oxalic Acid SCHEMBL11135886 | 0.97 | SIGMAR1 (0.70) | SIGMAR1THRATHRBKCNH2FDPS | |
| Oxalic Acid SCHEMBL11135893 | 0.97 | SIGMAR1 (0.70) | SIGMAR1THRATHRBKCNH2FDPS | |
| Oxalic Acid SCHEMBL8090960 | 0.94 | SIGMAR1 (0.68) | SIGMAR1THRATHRBKCNH2 | |
| SCHEMBL11130673 | 0.92 | SIGMAR1 (0.86) | SIGMAR1THRATHRBKCNH2FDPS | |
| SCHEMBL19253990 | 0.92 | SIGMAR1 (0.86) | SIGMAR1THRATHRBKCNH2FDPS | |
| SCHEMBL11567562 | 0.92 | SIGMAR1 (0.86) | SIGMAR1THRATHRBKCNH2FDPS | |
| Hydrochloric Acid SCHEMBL16336599 | 0.90 | SIGMAR1 (0.83) | SIGMAR1THRATHRBKCNH2FDPS | |
| SCHEMBL11131202 | 0.89 | SIGMAR1 (0.82) | SIGMAR1THRATHRBKCNH2 | |
| SCHEMBL29107028 | 0.89 | SIGMAR1 (0.82) | SIGMAR1THRATHRBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4395410-A | Quaternary ammonium antiarrhythmic drugs | ELI LILLY AND COMPANY (US) | 1983-07-26 | — | — | US | disclosed |
| EP-0002604-B1 | QUATERNARY AMMONIUM SALTS, AND THEIR FORMULATIONS AND PREPARATION | ELI LILLY AND COMPANY (US) | 1983-05-04 | — | — | EP | disclosed |
| US-4289787-A | PROLONG ACTION POTENTIAL OF CARDIAC TISSUE | ELI LILLY AND COMPANY (US) | 1981-09-15 | — | — | US | disclosed |
| EP-0002604-A1 | Quaternary ammonium salts, and their formulations and preparation | ELI LILLY AND COMPANY (US) | 1979-06-27 | — | — | EP | disclosed |