Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.68 |
| ▸ | THRA | P10827 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | EBP | Q15125 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL11134635 | 0.94 | SIGMAR1 (0.73) | SIGMAR1THRATHRBKCNH2 | |
| Oxalic Acid SCHEMBL11135893 | 0.94 | SIGMAR1 (0.70) | SIGMAR1THRATHRBKCNH2 | |
| Oxalic Acid SCHEMBL11134632 | 0.94 | SIGMAR1 (0.73) | SIGMAR1THRATHRBKCNH2 | |
| Oxalic Acid SCHEMBL11135886 | 0.94 | SIGMAR1 (0.70) | SIGMAR1THRATHRBKCNH2 | |
| SCHEMBL10802386 | 0.92 | SIGMAR1 (0.79) | SIGMAR1THRATHRBEBPKCNH2 | |
| SCHEMBL27611325 | 0.92 | SIGMAR1 (0.79) | SIGMAR1THRATHRBEBPKCNH2 | |
| SCHEMBL9392475 | 0.92 | SIGMAR1 (0.79) | SIGMAR1THRATHRBEBPKCNH2 | |
| SCHEMBL9377824 | 0.90 | SIGMAR1 (0.77) | SIGMAR1THRATHRBEBPKCNH2 | |
| SCHEMBL8099520 | 0.90 | SIGMAR1 (0.76) | SIGMAR1THRATHRBEBPKCNH2 | |
| Hydrochloric Acid SCHEMBL28021779 | 0.89 | SIGMAR1 (0.74) | SIGMAR1THRATHRBEBPKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |