Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 6/20 | 0.46 |
| ▸ | CES2 | O00748 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 5/20 | 0.40 |
| ▸ | PPARD | Q03181 | 5/20 | 0.40 |
| ▸ | PPARA | Q07869 | 5/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | TLR2 | O60603 | 2/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3874809 | 0.92 | NOS3 (0.46) | NOS3NOS1NOS2CES1CES2 | |
| SCHEMBL26287322 | 0.92 | CES1 (0.50) | NOS3NOS1NOS2CES1CES2 | |
| SCHEMBL11140046 | 0.90 | CES2 (0.50) | CES1CES2ALDH1A1TP53PPARG | |
| SCHEMBL28288932 | 0.90 | CES2 (0.52) | CES1CES2ALDH1A1AKR1B1PPARG | |
| SCHEMBL9770398 | 0.87 | CES2 (0.54) | CES1CES2ALDH1A1PPARGPPARD | |
| SCHEMBL11787118 | 0.87 | CES2 (0.54) | CES1CES2ALDH1A1PPARGPPARD | |
| SCHEMBL11472884 | 0.85 | CES1 (0.44) | NOS3NOS1NOS2CES1CES2 | |
| SCHEMBL3864451 | 0.84 | CES2 (0.46) | CES1CES2ALDH1A1AKR1B1TP53 | |
| SCHEMBL14478079 | 0.84 | CES2 (0.48) | CES1CES2ALDH1A1TP53PPARG | |
| SCHEMBL6234311 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4422953-A | SUBSTITUTED SUCCINIC ACIDS | PETROLITE CORPORATION (US) | 1983-12-27 | — | — | US | claimed |
| US-4422953-A | SUBSTITUTED SUCCINIC ACIDS | PETROLITE CORPORATION (US) | 1983-12-27 | — | — | US | disclosed |