Known targets — ChEMBL curated mechanism
S1PR1S1PR2S1PR3S1PR4S1PR5rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.36 |
| ▸ | P2RY10 | O00398 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5880986 | 0.88 | MEN1 (0.41) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL7624677 | 0.88 | MEN1 (0.41) | MEN1THRBHTTKMT2AMAPT | |
| Oleyl Sulfate SCHEMBL430286 | 0.88 | CNR2 (0.42) | CNR1LPAR1LPAR3LPAR2 | |
| Oleyl Sulfate SCHEMBL430289 | 0.88 | CNR2 (0.42) | CNR1LPAR1LPAR3LPAR2 | |
| Trolamine SCHEMBL8858341 | 0.83 | MEN1 (0.51) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL9005388 | 0.83 | MEN1 (0.50) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL9005393 | 0.83 | MEN1 (0.50) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL9229842 | 0.83 | MEN1 (0.50) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL9229835 | 0.83 | MEN1 (0.50) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL11766949 | 0.80 | MEN1 (0.51) | MEN1THRBHTTKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4369057-A | CHOLINE SALT OF 6-HYDROXY-3 (2H)-PYRIDAZINONE | KAO SOAP CO., LTD. (JP) | 1983-01-18 | — | — | US | disclosed |