Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | ACACB | O00763 | 3/20 | 0.53 |
| ▸ | CKS1B | P61024 | 1/20 | 0.53 |
| ▸ | SKP1 | P63208 | 1/20 | 0.53 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | LCAT | P04180 | 1/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.43 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.43 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11152923 | 0.84 | CKS1B (0.55) | ACACBCKS1BSKP1SKP2HSD11B1 | |
| SCHEMBL11148822 | 0.84 | CKS1B (0.57) | ACACBCKS1BSKP1SKP2HTR1A | |
| SCHEMBL16769730 | 0.83 | HRH3 (0.57) | HRH3ACACBHTR1AHTR2ADRD3 | |
| SCHEMBL11148907 | 0.83 | CKS1B (0.49) | ACACBCKS1BSKP1SKP2HTR1A | |
| SCHEMBL11148903 | 0.82 | HTR3E (0.57) | CKS1BSKP1SKP2HSD11B1PDCD1LG2 | |
| SCHEMBL13865726 | 0.78 | KDM4E (0.44) | HRH3ALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL3282708 | 0.78 | HRH3 (0.43) | HRH3ACACBHTR1AHTR2ADRD3 | |
| SCHEMBL3826847 | 0.76 | HTR3E (0.60) | HRH3ACACBCKS1BSKP1SKP2 | |
| SCHEMBL25233477 | 0.76 | CKS1B (0.47) | ACACBCKS1BSKP1SKP2CD274 | |
| SCHEMBL2301058 | 0.76 | CKS1B (0.60) | HRH3CKS1BSKP1SKP2SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4409228-A | ANOREXIGENIC AGENTS | SANOFI (FR) | 1983-10-11 | — | — | US | disclosed |
| EP-0045980-B1 | COMPOUNDS USEFUL IN THE PREPARATION OF AMINOPIPERIDINES WITH ANORECTIC PROPERTIES | SANOFI S.A. (FR) | 1983-10-05 | — | — | EP | disclosed |
| EP-0021973-B1 | ANORECTIC AMINO PIPERIDINES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | SANOFI S.A. (FR) | 1982-12-08 | — | — | EP | disclosed |
| EP-0045980-A1 | Compounds useful in the preparation of aminopiperidines with anorectic properties | SANOFI S.A. (FR) | 1982-02-17 | — | — | EP | disclosed |
| EP-0021973-A2 | Anorectic amino piperidines, process for their preparation and medicaments containing them | SANOFI S.A. (FR) | 1981-01-07 | — | — | EP | disclosed |