Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 18/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7899943 | 1.00 | ACHE (1.00) | ACHE | |
| SCHEMBL14500076 | 1.00 | ACHE (1.00) | ACHE | |
| Bromide SCHEMBL4726271 | 0.99 | ACHE (1.00) | ACHE | |
| SCHEMBL12306067 | 0.85 | ACHE (0.74) | ACHE | |
| SCHEMBL8010257 | 0.85 | ACHE (0.74) | ACHE | |
| SCHEMBL27820343 | 0.85 | ACHE (0.74) | ACHE | |
| SCHEMBL19781956 | 0.84 | ACHE (0.73) | ACHE | |
| SCHEMBL17321081 | 0.82 | ACHE (0.69) | ACHE | |
| SCHEMBL17321126 | 0.81 | ACHE (0.68) | ACHE | |
| SCHEMBL17321129 | 0.81 | ACHE (0.67) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278970-B1 | PROCESS FOR THE PREPARATION OF DONEPEZIL HYDROCHLORIDE | CIPLA LTD (IN) | 2015-04-22 | — | — | EP | disclosed |
| US-8987458-B2 | Process for the preparation of donepezil hydrochloride | CIPLA LIMITED (IN) | 2015-03-24 | — | — | US | disclosed |
| US-20110077271-A1 | Process for the Preparation of Donepezil Hydrochloride | CIPLA LIMITED (IN) | 2011-03-31 | — | — | US | disclosed |
| EP-2278970-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL HYDROCHLORIDE | Cipla Limited (IN) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009118516-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL HYDROCHLORIDE | CIPLA LIMITED (GB) | 2009-10-01 | — | — | WO | disclosed |
| US-20090137811-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | PLIVA HRVATSKA D.O.O | 2009-05-28 | — | — | US | disclosed |
| US-20090137811-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | PLIVA HRVATSKA D.O.O | 2009-05-28 | — | — | US | disclosed |
| US-7446203-B2 | Preparation of intermediates for acetycholinesterase inhibitors | HETERO DRUGS LIMITED (IN) | 2008-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137811-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | ACHE, BCHE, WIZ | ACHE 1/4885 |
| US-20110077271-A1 | Process for the Preparation of Donepezil Hydrochloride | ACHE, CHRNA5, BCHE | ACHE 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.