Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 4/20 | 0.68 |
| ▸ | RORC | P51449 | 3/20 | 0.68 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.68 |
| ▸ | USP2 | O75604 | 2/20 | 0.68 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.68 |
| ▸ | POLA1 | P09884 | 1/20 | 0.66 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.59 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.58 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.58 |
| ▸ | FNTA | P49354 | 1/20 | 0.56 |
| ▸ | FNTB | P49356 | 1/20 | 0.56 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.56 |
| ▸ | CRYAB | P02511 | 1/20 | 0.56 |
| ▸ | HMGCR | P04035 | 1/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.56 |
| ▸ | ITGAV | P06756 | 1/20 | 0.56 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL162526 | 0.92 | OSBP (0.82) | OSBPRORCCYP46A1USP2OSBP2 | |
| Cholesterol SCHEMBL29065777 | 0.92 | OSBP (0.82) | OSBPRORCCYP46A1USP2OSBP2 | |
| Cholesterol SCHEMBL28035647 | 0.92 | OSBP (0.82) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL13190668 | 0.89 | OSBP (0.80) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL26596 | 0.89 | OSBP (0.80) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL24203082 | 0.89 | OSBP (0.80) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL16131075 | 0.89 | OSBP (0.80) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL8421833 | 0.89 | OSBP (0.80) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL22417648 | 0.89 | OSBP (0.80) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL16131076 | 0.89 | OSBP (0.80) | OSBPRORCCYP46A1USP2OSBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4370497-A | Oxidation process using tellurium oxide catalysts | BARTON DEREK H R (FR) | 1983-01-25 | — | — | US | disclosed |