Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Cholesterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.65 |
| ▸ | OSBP | P22059 | 4/20 | 0.82 |
| ▸ | RORC | P51449 | 3/20 | 0.82 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.82 |
| ▸ | USP2 | O75604 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 1/20 | 0.82 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.82 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.82 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.71 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.71 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.70 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.70 |
| ▸ | NPC1L1 | Q9UHC9 | 3/20 | 0.67 |
| ▸ | CRYAB | P02511 | 1/20 | 0.67 |
| ▸ | HMGCR | P04035 | 1/20 | 0.67 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.67 |
| ▸ | ITGAV | P06756 | 1/20 | 0.67 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.67 |
| ▸ | POLA1 | P09884 | 1/20 | 0.66 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL29065777 | 1.00 | OSBP (0.82) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL162526 | 1.00 | OSBP (0.82) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL1296896 | 0.93 | OSBP (0.82) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL29033213 | 0.93 | OSBP (0.82) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27608874 | 0.93 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27668883 | 0.92 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL1369602 | 0.92 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL29502101 | 0.92 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27942138 | 0.92 | OSBP (0.96) | OSBPRORCOSBP2USP2LMNA | |
| Benzoic Acid SCHEMBL11147682 | 0.92 | OSBP (0.68) | OSBPRORCOSBP2USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105017366-B | The ketone group cholesterol biosynthesis method of 25 hydroxyl 7 | 浙江工业大学 | 2018-02-27 | — | — | CN | disclosed |
| CN-104910231-B | A kind of synthetic method of 25-hydroxyl-7-DHC | 浙江工业大学 | 2016-08-24 | — | — | CN | disclosed |
| CN-105017366-A | Synthesis method for 25-hydroxy-7-ketocholesterol | UNIV ZHEJIANG TECHNOLOGY | 2015-11-04 | — | — | CN | disclosed |
| CN-104910231-A | 25-hydroxy-7-dehydrocholesterol synthetic method | UNIV ZHEJIANG TECHNOLOGY | 2015-09-16 | — | — | CN | disclosed |