Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 6/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11157099 | 0.90 | TSHR (0.59) | AKR1B1TSHRTDP1 | |
| SCHEMBL10153099 | 0.86 | AKR1B1 (0.60) | AKR1B1TSHRTDP1CASP6 | |
| SCHEMBL11153129 | 0.81 | KDM1A (0.44) | AKR1B1 | |
| SCHEMBL11152497 | 0.81 | KDM1A (0.44) | AKR1B1 | |
| SCHEMBL11153227 | 0.80 | AKR1B1 (0.40) | AKR1B1 | |
| SCHEMBL11150122 | 0.80 | ALDH1A1 (0.41) | AKR1B1ALDH1A1 | |
| SCHEMBL11147835 | 0.78 | AKR1B1 (0.38) | AKR1B1TSHRTDP1 | |
| SCHEMBL11151959 | 0.77 | CYP3A4 (0.46) | AKR1B1TSHRALDH1A1 | |
| SCHEMBL11149963 | 0.76 | CYP2C19 (0.53) | AKR1B1ALDH1A1 | |
| SCHEMBL11153709 | 0.76 | AKR1B1 (0.38) | AKR1B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028485-B1 | SPIRO-IMIDAZOLONES FOR ALLEVIATING DIABETES-ASSOCIATED CONDITIONS, PROCESSES FOR PREPARING THEM, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1983-08-24 | — | — | EP | claimed |
| US-4283409-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1981-08-11 | — | — | US | claimed |
| EP-0028485-A1 | Spiro-imidazolones for alleviating diabetes-associated conditions, processes for preparing them, and pharmaceutical compositions containing them | PFIZER INC. (US) | 1981-05-13 | — | — | EP | claimed |
| EP-0028485-B1 | SPIRO-IMIDAZOLONES FOR ALLEVIATING DIABETES-ASSOCIATED CONDITIONS, PROCESSES FOR PREPARING THEM, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1983-08-24 | — | — | EP | disclosed |
| US-4283409-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1981-08-11 | — | — | US | disclosed |
| US-4283409-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1981-08-11 | — | — | US | disclosed |
| EP-0028485-A1 | Spiro-imidazolones for alleviating diabetes-associated conditions, processes for preparing them, and pharmaceutical compositions containing them | PFIZER INC. (US) | 1981-05-13 | — | — | EP | disclosed |