Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11160587 | 0.92 | CYP2C19 (0.44) | CYP2C19KDM1ATNFPDE3BPDE3A | |
| SCHEMBL11151959 | 0.91 | CYP3A4 (0.46) | CYP2C19KDM1AAKR1B1RAB9AALDH1A1 | |
| SCHEMBL11154633 | 0.83 | CYP3A4 (0.48) | CYP2C19PDE3BPDE3AALDH1A1CYP3A4 | |
| SCHEMBL11150122 | 0.83 | ALDH1A1 (0.41) | CYP2C19AKR1B1ALDH1A1CYP3A4 | |
| SCHEMBL11145299 | 0.82 | MAPK1 (0.40) | CYP2C19AKR1B1RAB9AALDH1A1MAPK1 | |
| SCHEMBL9176801 | 0.81 | AKR1B1 (0.60) | CYP2C19KDM1AAKR1B1TNFPDE7A | |
| SCHEMBL11153227 | 0.80 | AKR1B1 (0.40) | CYP2C19AKR1B1LMNA | |
| SCHEMBL11147883 | 0.76 | AKR1B1 (0.61) | AKR1B1ALDH1A1 | |
| SCHEMBL11346786 | 0.76 | LMNA (0.42) | ALDH1A1LMNA | |
| SCHEMBL11147581 | 0.75 | AKR1B1 (0.34) | CYP2C19AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028485-B1 | SPIRO-IMIDAZOLONES FOR ALLEVIATING DIABETES-ASSOCIATED CONDITIONS, PROCESSES FOR PREPARING THEM, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1983-08-24 | — | — | EP | disclosed |
| US-4283409-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1981-08-11 | — | — | US | disclosed |
| EP-0028485-A1 | Spiro-imidazolones for alleviating diabetes-associated conditions, processes for preparing them, and pharmaceutical compositions containing them | PFIZER INC. (US) | 1981-05-13 | — | — | EP | disclosed |