Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL30537324 | 1.00 | ALDH1A1 (0.62) | ALDH1A1PDE4ALMNAL3MBTL1USP2 | |
| Citric Acid SCHEMBL30395475 | 1.00 | ALDH1A1 (0.62) | ALDH1A1PDE4ALMNAL3MBTL1USP2 | |
| Citric Acid SCHEMBL28502932 | 1.00 | ALDH1A1 (0.62) | ALDH1A1PDE4ALMNAL3MBTL1USP2 | |
| Citric Acid SCHEMBL20481449 | 1.00 | ALDH1A1 (0.62) | ALDH1A1PDE4ALMNAL3MBTL1USP2 | |
| Citric Acid SCHEMBL28453284 | 0.98 | ALDH1A1 (0.60) | ALDH1A1PDE4ALMNAL3MBTL1USP2 | |
| Citric Acid SCHEMBL12006103 | 0.98 | ALDH1A1 (0.60) | ALDH1A1PDE4ALMNAL3MBTL1USP2 | |
| Citric Acid SCHEMBL2785421 | 0.96 | ALDH1A1 (0.58) | ALDH1A1PDE4ALMNAL3MBTL1USP2 | |
| Citric Acid SCHEMBL27176009 | 0.96 | ALDH1A1 (0.62) | ALDH1A1PDE4ALMNAL3MBTL1USP2 | |
| Citric Acid SCHEMBL17894110 | 0.96 | ALDH1A1 (0.62) | ALDH1A1PDE4ALMNAL3MBTL1USP2 | |
| Citric Acid SCHEMBL22749153 | 0.93 | ALDH1A1 (0.54) | ALDH1A1PDE4ALMNAL3MBTL1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247284-B1 | PROCESS TO MINIMIZE POLYMORPHISM | SCHERER TECHNOLOGIES LLC R P (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2016118921-A1 | COMPOSITIONS AND METHODS FOR TREATING PSORIATIC ARTHRITIS | ABBVIE, INC. (US) | 2016-07-28 | — | — | WO | disclosed |
| WO-2015138337-A1 | COMPOSITIONS AND METHODS FOR TREATING RHEUMATOID ARTHRITIS | ABBVIE, INC. (US) | 2015-09-17 | — | — | WO | disclosed |
| US-4412986-A | COPRECIPITATED WITH POLYVINYLPYRROLIDONE OR A CELLULOSE ETHER | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1983-11-01 | — | — | US | disclosed |