Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CPT2 | P23786 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL30537324 | 0.93 | ALDH1A1 (0.62) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL28502932 | 0.93 | ALDH1A1 (0.62) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL11147980 | 0.93 | ALDH1A1 (0.62) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL20481449 | 0.93 | ALDH1A1 (0.62) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL30395475 | 0.93 | ALDH1A1 (0.62) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL28453284 | 0.91 | ALDH1A1 (0.60) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL12006103 | 0.91 | ALDH1A1 (0.60) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL2785421 | 0.89 | ALDH1A1 (0.58) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL27176009 | 0.89 | ALDH1A1 (0.62) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL17894110 | 0.89 | ALDH1A1 (0.62) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240016831-A1 | NITRIC OXIDE OR NITRIC OXIDE RELEASING COMPOSITIONS FOR USE IN TREATING SARS-COV AND SARS-COV-2 | Thirty Respiratory Limited (GB) | 2024-01-18 | — | — | US | disclosed |
| US-20230172973-A1 | METHODS AND COMPOSITIONS FOR TREATING AND COMBATTING TUBERCULOSIS | Thirty Respiratory Limited (GB) | 2023-06-08 | — | — | US | disclosed |
| CN-115884758-A | Nitric oxide or nitric oxide-releasing compositions for the treatment of SARS-CoV and SARS-CoV-2 | 三十呼吸有限公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-115768413-A | Methods and compositions for treating and combating tuberculosis | 三十呼吸有限公司 | 2023-03-07 | — | — | CN | disclosed |
| EP-4138794-A1 | METHODS AND COMPOSITIONS FOR TREATING AND COMBATTING TUBERCULOSIS | THIRTY RESPIRATORY LIMITED (GB) | 2023-03-01 | — | — | EP | disclosed |
| US-20220370493-A1 | METHODS AND COMPOSITIONS FOR GENERATING NITRIC OXIDE AND USES THEREOF | Thirty Holdings Limited (GB) | 2022-11-24 | — | — | US | disclosed |
| EP-3980373-A1 | METHODS AND COMPOSITIONS FOR GENERATING NITRIC OXIDE AND USES THEREOF | THIRTY HOLDINGS LIMITED (GB) | 2022-04-13 | — | — | EP | disclosed |
| CN-114206325-A | Methods and compositions for generating nitric oxide and uses thereof | 三十控股有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-114126629-A | Methods and compositions for generating nitric oxide and uses thereof for delivery of nitric oxide via the respiratory tract | 三十呼吸有限公司 | 2022-03-01 | — | — | CN | disclosed |
| WO-2021214439-A1 | METHODS AND COMPOSITIONS FOR TREATING AND COMBATTING TUBERCULOSIS | Thirty Respiratory Limited (GB) | 2021-10-28 | — | — | WO | disclosed |
| WO-2020245573-A1 | METHODS AND COMPOSITIONS FOR GENERATING NITRIC OXIDE AND USES THEREOF | Thirty Holdings Limited (GB) | 2020-12-10 | — | — | WO | disclosed |