Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11635971 | 0.85 | KMT2A (0.62) | KMT2ASTAT3KDM4EALDH1A1MAPT | |
| SCHEMBL14564434 | 0.80 | KDM4E (0.47) | KMT2APTGDR2KDM4EALDH1A1POLB | |
| SCHEMBL16536117 | 0.76 | ALDH1A1 (0.51) | KMT2APTGDR2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL16536006 | 0.75 | ALDH1A1 (0.50) | KMT2APTGDR2KDM4EALDH1A1 | |
| SCHEMBL2989115 | 0.75 | MAPT (0.43) | KMT2AALDH1A1POLBMAPT | |
| SCHEMBL11192940 | 0.70 | KMT2A (0.47) | KMT2ASTAT3KDM4EALDH1A1MAPT | |
| SCHEMBL3169119 | 0.68 | KMT2A (0.57) | KMT2ARHEBSTAT3KDM4EALDH1A1 | |
| SCHEMBL23885112 | 0.68 | KMT2A (0.45) | KMT2ARHEBPTGDR2STAT3KDM4E | |
| SCHEMBL30053871 | 0.68 | KMT2A (0.45) | KMT2ARHEBPTGDR2STAT3KDM4E | |
| SCHEMBL20596484 | 0.67 | GRIN1 (0.41) | RHEBPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4382088-A | DIABETIC COMPLICATIONS, ALDOSE REDUCTASE INHIBITORS | AYERST, MCKENNA & HARRISON, INC. (CA) | 1983-05-03 | — | — | US | disclosed |