SCHEMBL11150239

SCHEMBL11150239

CCNCCN1CCN(c2cccc(C(F)(F)F)c2)CC1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 2/20 0.62
CACNA1G O43497 4/20 0.60
ALDH1A1 P00352 2/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
HTR1A P08908 2/20 0.58
CYP1A2 P05177 1/20 0.58
CYP3A4 P08684 1/20 0.58
CYP2D6 P10635 1/20 0.58
MAPT P10636 1/20 0.58
TSHR P16473 1/20 0.58
NFKB1 P19838 1/20 0.58
MAPK1 P28482 1/20 0.58
CYP2C19 P33261 1/20 0.58
THPO P40225 1/20 0.58
MTOR P42345 1/20 0.58
BLM P54132 1/20 0.58
PMP22 Q01453 1/20 0.58
TDP1 Q9NUW8 1/20 0.58
LMNA P02545 1/20 0.58
HTR7 P34969 4/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Formamide SCHEMBL11151879 0.94 SIGMAR1 (0.56) SIGMAR1CACNA1GALDH1A1SMN1; SMN2HTR1A
SCHEMBL11286821 0.87 SIGMAR1 (0.64) SIGMAR1ALDH1A1SMN1; SMN2HTR1ACYP1A2
SCHEMBL2927397 0.85 ALDH1A1 (0.77) SIGMAR1ALDH1A1SMN1; SMN2HTR1ACYP1A2
Ammonia Solution, Strong SCHEMBL11284383 0.84 ALDH1A1 (0.75) SIGMAR1ALDH1A1SMN1; SMN2HTR1ACYP1A2
SCHEMBL11285621 0.84 SIGMAR1 (0.60) SIGMAR1ALDH1A1SMN1; SMN2HTR1ACYP1A2
Hydrochloric Acid SCHEMBL11642305 0.83 SIGMAR1 (0.60) SIGMAR1CACNA1GALDH1A1SMN1; SMN2HTR1A
SCHEMBL13875120 0.83 SIGMAR1 (0.69) SIGMAR1ALDH1A1SMN1; SMN2HTR1ACYP1A2
Hydrochloric Acid SCHEMBL11445695 0.82 SIGMAR1 (0.59) SIGMAR1ALDH1A1SMN1; SMN2HTR1ACYP1A2
SCHEMBL11465528 0.82 SIGMAR1 (0.76) SIGMAR1ALDH1A1SMN1; SMN2HTR1ACYP1A2
SCHEMBL6926448 0.82 SIGMAR1 (0.64) SIGMAR1ALDH1A1SMN1; SMN2HTR1ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0015615-B1 PHENYL PIPERAZINE DERIVATIVES, THEIR PREPARATION AND ANTIAGRESSIVE MEDICINES CONTAINING THEM DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1983-01-12 EP disclosed
EP-0015615-A1 Phenyl piperazine derivatives, their preparation and antiagressive medicines containing them DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1980-09-17 EP disclosed