Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1111625 | 0.88 | ALDH1A1 (0.44) | CHRNA7ALDH1A1HTTKLKB1MEN1 | |
| SCHEMBL3404458 | 0.87 | CHRNA7 (0.56) | CHRNA7KLKB1ADRB2CACNA1GCACNA1H | |
| SCHEMBL1115228 | 0.86 | PDE2A (0.45) | CHRNA7ALDH1A1KLKB1MEN1KMT2A | |
| SCHEMBL3427389 | 0.83 | CHRNA7 (0.49) | CHRNA7ALDH1A1KLKB1ADRB2CACNA1G | |
| SCHEMBL1111628 | 0.83 | JUN (0.44) | ALDH1A1HTTKLKB1MEN1KMT2A | |
| SCHEMBL7999517 | 0.82 | ALDH1A1 (0.44) | CHRNA7ALDH1A1HTTKLKB1MEN1 | |
| SCHEMBL7987284 | 0.80 | EPHX2 (0.56) | CHRNA7ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL1111656 | 0.80 | POLB (0.46) | CHRNA7ALDH1A1HTTKLKB1MEN1 | |
| SCHEMBL1111565 | 0.79 | KLKB1 (0.46) | CHRNA7ALDH1A1HTTKLKB1MEN1 | |
| SCHEMBL7996732 | 0.79 | ALDH1A1 (0.44) | ALDH1A1HTTKLKB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034515-A1 | INDOLE MODULATORS OF THE ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | GLAXOSMITHKLINE SERVICES UNLIMITED (GB) | 2011-02-10 | — | — | US | claimed |
| EP-2279184-A1 | INDOLE MODULATORS OF THE ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR | Glaxo Group Limited (GB) | 2011-02-02 | — | — | EP | claimed |
| WO-2009127678-A1 | INDOLES AS MODULATORS OF NICOTINIC ACETYLCHOLIN RECEPTOR SUBTYPE ALPHA-71 | GLAXO GROUP LIMITED (GB) | 2009-10-22 | — | — | WO | claimed |
| US-20110034515-A1 | INDOLE MODULATORS OF THE ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | GLAXOSMITHKLINE SERVICES UNLIMITED (GB) | 2011-02-10 | — | — | US | disclosed |
| EP-2279184-A1 | INDOLE MODULATORS OF THE ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR | Glaxo Group Limited (GB) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009127678-A1 | INDOLES AS MODULATORS OF NICOTINIC ACETYLCHOLIN RECEPTOR SUBTYPE ALPHA-71 | GLAXO GROUP LIMITED (GB) | 2009-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034515-A1 | INDOLE MODULATORS OF THE ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | CHRNA7, CHRNA5, CHRNG | CHRNA7 1/4885ALDH1A1 1122/4885HTT 2908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.