Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | CDC7 | O00311 | 2/20 | 0.53 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | DHODH | Q02127 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11159408 | 0.89 | MAPT (0.62) | TRPM8ALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL3893108 | 0.86 | ALDH1A1 (0.71) | TRPM8ALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL1340065 | 0.86 | TRPM8 (0.62) | TRPM8ALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL2491226 | 0.86 | MEN1 (0.62) | TRPM8ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL11160196 | 0.84 | ALDH1A1 (0.76) | TRPM8ALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL11281533 | 0.83 | PTPN11 (0.57) | TRPM8ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL7839943 | 0.80 | TRPM8 (0.55) | TRPM8ALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL11281010 | 0.80 | ALDH1A1 (0.55) | TRPM8ALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL2492109 | 0.80 | TRPM8 (0.65) | TRPM8ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL11289926 | 0.79 | DHODH (0.51) | TRPM8ALDH1A1MAPTHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4377693-A | 2-Chloro-4,5-disubstituted-thiazoles useful as herbicidal safeners | MONSANTO COMPANY (US) | 1983-03-22 | — | — | US | disclosed |
| US-4377054-A | Seed coated with 2-chloro-4,5-disubstituted-thiazole derivatives which are herbicidal safeners | MONSANTO COMPANY (US) | 1983-03-22 | — | — | US | disclosed |
| EP-0027019-B1 | 2-CHLORO-4,5-DISUBSTITUTED-THIAZOLES, PROCESS FOR THEIR PREPARATION, USE AS ANTIDOTES AGAINST DAMAGE CAUSED BY HERBICIDES AND MIXTURES CONTAINING THEM | MONSANTO COMPANY (US) | 1983-02-16 | — | — | EP | disclosed |
| US-4371389-A | ACETANILIDE HERBICIDES, SORGHUM | MONSANTO COMPANY (US) | 1983-02-01 | — | — | US | disclosed |
| US-4336389-A | 2-Substituted-4-aryl-5-thiazolecarboxylic acids and their derivatives as safening agents | MONSANTO COMPANY (US) | 1982-06-22 | — | — | US | disclosed |
| US-4284426-A | 2-Chloro-4,5-disubstituted-thiazoles useful as herbicidal safeners | MONSANTO COMPANY (US) | 1981-08-18 | — | — | US | disclosed |
| EP-0027019-A1 | 2-Chloro-4,5-disubstituted-thiazoles, process for their preparation, use as antidotes against damage caused by herbicides and mixtures containing them | MONSANTO COMPANY (US) | 1981-04-15 | — | — | EP | disclosed |