Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | CDC25B | P30305 | 2/20 | 0.53 |
| ▸ | CDC25A | P30304 | 1/20 | 0.53 |
| ▸ | CDC25C | P30307 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11387390 | 0.87 | TSHR (0.49) | TSHRLMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL27901950 | 0.87 | CYP3A4 (0.68) | TSHRLMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL11062628 | 0.86 | KDM4E (0.62) | TSHRLMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1460556 | 0.83 | TSHR (0.67) | TSHRLMNAALDH1A1KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL6383958 | 0.81 | TSHR (0.65) | TSHRLMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2510669 | 0.81 | MAPT (0.48) | LMNAALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL9592036 | 0.81 | TP53 (0.47) | TSHRLMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL11071275 | 0.80 | ALDH1A1 (0.43) | TSHRLMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL5180569 | 0.80 | GAA (0.48) | LMNAALDH1A1KDM4EHSD17B10CYP1A2 | |
| SCHEMBL11159593 | 0.80 | TSHR (0.62) | TSHRLMNAALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0018139-B1 | PYRIDO (2,3-D) PYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR PREPARING THE PYRIDO (2,3-D) PYRIMIDINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-05-04 | — | — | EP | disclosed |
| US-4301281-A | 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]-pyrimidine-6-carboxylic acid amides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-11-17 | — | — | US | disclosed |
| US-4255568-A | ANTIALLERGENS AND ANTISECRETORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |
| US-4236004-A | 2-Alkylsulphonyl-7,8-dihydro-5-hydroxy-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-11-25 | — | — | US | disclosed |
| US-4233446-A | 5-Chloro-7,8-dihydro-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-11-11 | — | — | US | disclosed |
| EP-0018139-A2 | Pyrido (2,3-d) pyrimidine derivatives, pharmaceutical compositions containing them and processes for preparing the pyrido (2,3-d) pyrimidine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-10-29 | — | — | EP | disclosed |
| US-4215216-A | 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-07-29 | — | — | US | disclosed |