Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TET2 | Q6N021 | 1/20 | 0.71 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.71 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL703592 | 0.83 | TET2 (1.00) | TET2TET1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL22545416 | 0.82 | TET2 (0.79) | TET2TET1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL17237877 | 0.76 | TET2 (0.69) | TET2TET1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL18306013 | 0.76 | ADORA2A (0.55) | TET2TET1KMT2A | |
| SCHEMBL13310738 | 0.76 | TET2 (0.65) | TET2TET1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL22545520 | 0.72 | TET2 (0.66) | TET2TET1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL3415803 | 0.72 | LMNA (0.71) | LMNAMETAP2METAP1HDAC6MAPT | |
| SCHEMBL377229 | 0.71 | LMNA (0.50) | TET2TET1LMNAMETAP2METAP1 | |
| SCHEMBL7016593 | 0.71 | TET2 (0.55) | TET2TET1LMNAMAPTKDM4E | |
| SCHEMBL22545420 | 0.71 | TET2 (0.64) | TET2TET1CSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919463-B9 | USE OF HIF 1ALFA MODULATORS FOR TREATMENT OF CANCER | FIBROGEN INC (US) | 2011-02-02 | — | — | EP | claimed |
| EP-1919463-B1 | USE OF HIF 1ALFA MODULATORS FOR TREATMENT OF CANCER | FIBROGEN INC (US) | 2010-06-09 | — | — | EP | claimed |