Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.41 |
| ▸ | TSHR | P16473 | 8/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 11/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.39 |
| ▸ | CASP1 | P29466 | 6/20 | 0.39 |
| ▸ | USP2 | O75604 | 6/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11159602 | 0.79 | MAPT (0.41) | HSD17B10TSHRHPGDMAPTSMN1; SMN2 | |
| SCHEMBL11164347 | 0.74 | CYP1A2 (0.45) | HSD17B10TSHRHPGDMAPTSMN1; SMN2 | |
| SCHEMBL11350483 | 0.72 | ALDH1A1 (0.42) | HSD17B10TSHRHPGDMAPTSMN1; SMN2 | |
| SCHEMBL10691914 | 0.63 | HSP90AA1 (0.41) | TSHRSMN1; SMN2KDM4EALDH1A1MAPK1 | |
| SCHEMBL1457557 | 0.62 | HTT (0.66) | HSD17B10TSHRHPGDMAPTSMN1; SMN2 | |
| SCHEMBL266418 | 0.62 | RAB9A (0.54) | HSD17B10TSHRHPGDMAPTSMN1; SMN2 | |
| SCHEMBL7861772 | 0.61 | MAPT (0.66) | HSD17B10TSHRHPGDMAPTSMN1; SMN2 | |
| SCHEMBL18980077 | 0.60 | RAB9A (0.58) | MAPTSMN1; SMN2CYP1A2ALDH1A1CYP3A4 | |
| SCHEMBL11155724 | 0.60 | ALDH1A1 (0.41) | HSD17B10TSHRHPGDMAPTCYP1A2 | |
| SCHEMBL17140101 | 0.60 | MEN1 (0.40) | HSD17B10TSHRHPGDMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0032131-B1 | 5-HALO-PYRIMIDIN-2-ONES, THE SALTS THEREOF, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NYEGAARD & CO. A/S (NO) | 1983-09-21 | — | — | EP | disclosed |
| US-4399140-A | CYTOTOXIC | NYEGAARD & CO. A/S (NO) | 1983-08-16 | — | — | US | disclosed |
| EP-0032131-A1 | 5-Halo-pyrimidin-2-ones, the salts thereof, processes for their preparation and pharmaceutical compositions containing them | NYEGAARD & CO. A/S (NO) | 1981-07-15 | — | — | EP | disclosed |