Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ASPH | Q12797 | 2/20 | 0.53 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.53 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.52 |
| ▸ | VNN1 | O95497 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.49 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11159729 | 0.88 | ALDH1A1 (0.66) | ALDH1A1MEN1KMT2AHTTKDM4E | |
| SCHEMBL34462257 | 0.82 | KDM4E (0.53) | ALDH1A1MEN1KMT2AKDM4EASPH | |
| SCHEMBL16824948 | 0.81 | KDM4E (0.54) | ALDH1A1MEN1KMT2AHTTKDM4E | |
| SCHEMBL34462321 | 0.81 | KDM4E (0.54) | ALDH1A1KDM4EASPHKDM8RIOX2 | |
| SCHEMBL11160675 | 0.79 | MEN1 (0.51) | ALDH1A1MEN1KMT2AHTTKDM4E | |
| SCHEMBL3255471 | 0.79 | MEN1 (0.54) | ALDH1A1MEN1KMT2AHTTLMNA | |
| SCHEMBL11162717 | 0.79 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AHTTKDM4E | |
| SCHEMBL34462329 | 0.79 | KDM4E (0.52) | ALDH1A1KDM4EASPHKDM8RIOX2 | |
| SCHEMBL34462355 | 0.79 | JAK3 (0.54) | KDM4EASPHKDM8RIOX2VNN1 | |
| SCHEMBL11164512 | 0.78 | NPSR1 (0.67) | ALDH1A1MEN1KMT2AHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0018139-B1 | PYRIDO (2,3-D) PYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR PREPARING THE PYRIDO (2,3-D) PYRIMIDINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-05-04 | — | — | EP | disclosed |
| US-4301281-A | 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]-pyrimidine-6-carboxylic acid amides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-11-17 | — | — | US | disclosed |
| US-4255568-A | ANTIALLERGENS AND ANTISECRETORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |
| US-4236004-A | 2-Alkylsulphonyl-7,8-dihydro-5-hydroxy-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-11-25 | — | — | US | disclosed |
| US-4233446-A | 5-Chloro-7,8-dihydro-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-11-11 | — | — | US | disclosed |
| EP-0018139-A2 | Pyrido (2,3-d) pyrimidine derivatives, pharmaceutical compositions containing them and processes for preparing the pyrido (2,3-d) pyrimidine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-10-29 | — | — | EP | disclosed |
| US-4215216-A | 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-07-29 | — | — | US | disclosed |