Urea

Urea

SCHEMBL11159986

C=CC(=O)NC(C=C)NC(=O)C=C.NC(N)=O

nearest known ligand 0.50

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Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.50
ALDH1A1 P00352 2/20 0.39
FGFR4 P22455 1/20 0.39
CYP2C19 P33261 1/20 0.37
MAPK1 P28482 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
TGM2 P21980 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Urea SCHEMBL1782560 0.77 TSHR (0.58) TSHRALDH1A1FGFR4CYP2C19MAPK1
SCHEMBL8956995 0.77 TSHR (0.38) TSHRALDH1A1FGFR4CYP2C19
SCHEMBL31376434 0.74 TSHR (0.48) TSHRALDH1A1FGFR4CYP2C19MAPK1
SCHEMBL9320738 0.74 TSHR (0.43) TSHRALDH1A1CYP2C19MAPK1TDP1
SCHEMBL300034 0.73
Hydrochloric Acid SCHEMBL6415353 0.71 TSHR (0.50) TSHRALDH1A1FGFR4CYP2C19MAPK1
SCHEMBL28116094 0.71 TSHR (0.50) TSHRALDH1A1FGFR4CYP2C19MAPK1
SCHEMBL28681811 0.71 TSHR (0.56) TSHRALDH1A1FGFR4CYP2C19MAPK1
Urea SCHEMBL27709911 0.71 ALDH1A1 (0.50) TSHRALDH1A1FGFR4CYP2C19MAPK1
SCHEMBL327708 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4421855-A CATIONIC ACRYLAMIDE-BASED POLYMER GEL NITTO CHEMICAL INDUSTRY CO., LTD. (JP) 1983-12-20 US disclosed