Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 13/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11158725 | 0.89 | AKR1B1 (0.58) | KMT2AAKR1B1CYP2C9PPARG | |
| SCHEMBL11172544 | 0.89 | AKR1B1 (0.59) | KMT2AAKR1B1CYP2C9PPARGPTGDR2 | |
| SCHEMBL11165764 | 0.87 | AKR1B1 (0.54) | KMT2AAKR1B1CYP2C9PPARGPTGDR2 | |
| SCHEMBL11160841 | 0.86 | AKR1B1 (0.58) | KMT2AAKR1B1CYP2C9PPARGPTGDR2 | |
| SCHEMBL11168814 | 0.84 | AKR1B1 (0.58) | KMT2AAKR1B1CYP2C9PPARGPTGDR2 | |
| SCHEMBL11169141 | 0.79 | ALDH1A1 (0.62) | KMT2AAKR1B1CYP2C9PPARGPTGDR2 | |
| SCHEMBL11169969 | 0.77 | ALDH1A1 (0.59) | AKR1B1CYP2C9PPARGPTGDR2ALDH1A1 | |
| SCHEMBL11163802 | 0.77 | KMT2A (0.64) | KMT2AAKR1B1CYP2C9ALDH1A1MAPT | |
| SCHEMBL11596000 | 0.77 | ALDH1A1 (0.62) | KMT2AAKR1B1CYP2C9PPARGPTGDR2 | |
| SCHEMBL11172068 | 0.74 | CYP2C9 (0.71) | KMT2ACYP2C9PPARGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4393062-A | ALDOSE REDUCTASE INHIBITOR | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-07-12 | — | — | US | disclosed |
| EP-0002895-B1 | ENZYME INHIBITORY PHTHALAZIN-4-YLACETIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND PROCESS FOR THEIR MANUFACTURE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-10-14 | — | — | EP | disclosed |
| US-4251528-A | ALDOSE REDUCTASE INHIBITORS USEFUL IN DIABETES, GALACTOSEMIA | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-02-17 | — | — | US | disclosed |