Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116161 | 1.00 | HTR2A (0.42) | HTR2APIK3CGCA2CA1CLK1 | |
| SCHEMBL1116224 | 0.81 | HTR2A (0.41) | HTR2APIK3CGCA2CA1CLK1 | |
| SCHEMBL1116221 | 0.81 | HTR2A (0.41) | HTR2APIK3CGCA2CA1CLK1 | |
| SCHEMBL1116169 | 0.81 | CA2 (0.42) | HTR2APIK3CGCA2CA1CLK1 | |
| SCHEMBL1116168 | 0.81 | CA2 (0.42) | HTR2APIK3CGCA2CA1CLK1 | |
| SCHEMBL1116258 | 0.80 | CLK1 (0.38) | PIK3CGCA2CA1CLK1CLK2 | |
| SCHEMBL1116259 | 0.80 | CLK1 (0.38) | PIK3CGCA2CA1CLK1CLK2 | |
| SCHEMBL6860968 | 0.77 | GSK3A (0.44) | PIK3CGBTKKMT2AMAPTMEN1 | |
| SCHEMBL1116164 | 0.77 | HTR2A (0.60) | HTR2APIK3CGCA2CA1CLK1 | |
| SCHEMBL1116160 | 0.77 | HTR2A (0.60) | HTR2APIK3CGCA2CA1CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011015646-A2 | FURAN-IMIDAZOLONE DERIVATIVES, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS | NOSCIRA, S.A. (ES) | 2011-02-10 | — | — | WO | disclosed |
| EP-2281824-A1 | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders | NOSCIRA, S.A. (ES) | 2011-02-09 | — | — | EP | disclosed |