Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | APP | P05067 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | UBE2N | P61088 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11162008 | 1.00 | LMNA (0.56) | LMNAKDM4EAPPALDH1A1THRB | |
| SCHEMBL3681804 | 0.85 | LMNA (0.60) | LMNAKDM4EAPPALDH1A1THRB | |
| SCHEMBL3672656 | 0.85 | LMNA (0.60) | LMNAKDM4EAPPALDH1A1THRB | |
| SCHEMBL2604928 | 0.84 | LCK (0.62) | LMNAKDM4EAPPALDH1A1THRB | |
| SCHEMBL7086043 | 0.84 | LMNA (0.59) | LMNAKDM4EAPPALDH1A1THRB | |
| SCHEMBL2092149 | 0.81 | LMNA (0.59) | LMNAKDM4EAPPALDH1A1THRB | |
| SCHEMBL4447847 | 0.81 | LMNA (0.59) | LMNAKDM4EAPPALDH1A1THRB | |
| SCHEMBL2092146 | 0.81 | LMNA (0.59) | LMNAKDM4EAPPALDH1A1THRB | |
| SCHEMBL2604940 | 0.81 | LMNA (0.58) | LMNAKDM4EAPPALDH1A1THRB | |
| SCHEMBL11335643 | 0.80 | LMNA (0.52) | LMNAKDM4EAPPALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0071399-A2 | Substituted pyrrolidine cardiovascular system regulators and antihypertensives, their preparation and use | SYNTEX (U.S.A.) INC. (US) | 1983-02-09 | — | — | EP | disclosed |