Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | UBE2N | P61088 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 4/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19649051 | 0.92 | HPGD (0.67) | LMNAALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL2604928 | 0.89 | LCK (0.62) | LMNAALDH1A1THRBKDM4EHPGD | |
| SCHEMBL4447847 | 0.83 | LMNA (0.59) | LMNAALDH1A1THRBKDM4EHPGD | |
| SCHEMBL28600024 | 0.81 | AKT1 (0.46) | LMNAALDH1A1THRBKDM4EMAPT | |
| SCHEMBL28600026 | 0.81 | AKT1 (0.46) | LMNAALDH1A1THRBKDM4EMAPT | |
| SCHEMBL11162005 | 0.81 | LMNA (0.56) | LMNAALDH1A1THRBKDM4EHPGD | |
| SCHEMBL11162008 | 0.81 | LMNA (0.56) | LMNAALDH1A1THRBKDM4EHPGD | |
| SCHEMBL2092146 | 0.80 | LMNA (0.59) | LMNAALDH1A1THRBKDM4EHPGD | |
| SCHEMBL2092149 | 0.80 | LMNA (0.59) | LMNAALDH1A1THRBKDM4EHPGD | |
| SCHEMBL19734612 | 0.80 | APP (0.70) | ALDH1A1KDM4EHPGDSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158380-B2 | Imaging agents for protein misfolding | NEW YORK UNIVERSITY (US) | 2012-04-17 | — | — | US | disclosed |
| US-8158380-B2 | Imaging agents for protein misfolding | NEW YORK UNIVERSITY (US) | 2012-04-17 | — | — | US | disclosed |
| US-20100279340-A1 | Imaging agents for protein misfolding | NYU (US) | 2010-11-04 | — | — | US | disclosed |
| US-20100279340-A1 | Imaging agents for protein misfolding | NYU (US) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100279340-A1 | Imaging agents for protein misfolding | APBA1, APP, SPG11 | LMNA 1999/4885ALDH1A1 3495/4885THRB 3669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.