Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | CFD | P00746 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 10/20 | 0.47 |
| ▸ | MAOB | P27338 | 10/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 3/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6862707 | 0.84 | KDM4E (0.58) | F2CFDMAOAMAOBACHE | |
| SCHEMBL9275028 | 0.79 | F2 (0.47) | F2CFDMAOAMAOBACHE | |
| SCHEMBL9276075 | 0.78 | MAOA (0.44) | F2CFDMAOAMAOBACHE | |
| SCHEMBL6870785 | 0.76 | MAOA (0.64) | F2CFDMAOAMAOBACHE | |
| SCHEMBL24616836 | 0.76 | F2 (0.47) | F2CFDMAOAMAOBACHE | |
| SCHEMBL9272079 | 0.75 | MAOA (0.55) | F2CFDMAOAMAOBACHE | |
| SCHEMBL11162914 | 0.74 | MAOA (0.43) | F2CFDMAOAMAOBACHE | |
| SCHEMBL1202291 | 0.74 | NOS1 (0.62) | F2CFDMAOAMAOBACHE | |
| SCHEMBL29891596 | 0.74 | NOS1 (0.62) | F2CFDMAOAMAOBACHE | |
| SCHEMBL1668291 | 0.70 | F2 (0.56) | F2CFDMAOAMAOBACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015065-B1 | PYRAZOLO (5,1-B) QUINAZOLIN-9(4H)-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY (US) | 1983-12-28 | — | — | EP | disclosed |
| US-4261996-A | ANTIHISTAMINES | WARNER-LAMBERT COMPANY (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0015065-A1 | Pyrazolo (5,1-b) quinazolin-9(4H)-one derivatives, process for their preparation and pharmaceutical compositions containing them | WARNER-LAMBERT COMPANY (US) | 1980-09-03 | — | — | EP | disclosed |