Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 5/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | PLAT | P00750 | 1/20 | 0.47 |
| ▸ | KLK1 | P06870 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11167226 | 0.86 | EPHX1 (0.59) | EPHX1ALDH1A1ALOX12CYP2C9CYP2C19 | |
| SCHEMBL11160273 | 0.85 | F10 (0.44) | ALDH1A1ALOX12CYP2C19NPSR1F10 | |
| SCHEMBL11439725 | 0.81 | ALDH1A1 (0.71) | EPHX1ALDH1A1ALOX12CYP2C9CYP2C19 | |
| SCHEMBL11166506 | 0.80 | ALDH1A1 (0.62) | EPHX1ALDH1A1ALOX12CYP2C9CYP2C19 | |
| SCHEMBL11162731 | 0.80 | EPHX1 (0.58) | EPHX1ALDH1A1ALOX12CYP2C9CYP2C19 | |
| SCHEMBL11105097 | 0.79 | EPHX1 (0.66) | EPHX1ALDH1A1ALOX12CYP2C9CYP2C19 | |
| SCHEMBL11165536 | 0.77 | EPHX1 (0.60) | EPHX1ALDH1A1ALOX12CYP2C9CYP2C19 | |
| SCHEMBL11170401 | 0.76 | EPHX1 (0.61) | EPHX1ALDH1A1ALOX12CYP2C9CYP2C19 | |
| SCHEMBL11168169 | 0.76 | EPHX1 (0.65) | EPHX1ALDH1A1ALOX12CYP2C9CYP2C19 | |
| SCHEMBL11161435 | 0.76 | EPHX1 (0.56) | EPHX1ALDH1A1ALOX12NPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0017484-B1 | 2-IMIDAZOLINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION OF THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-04-06 | — | — | EP | disclosed |
| EP-0017484-A1 | 2-Imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-10-15 | — | — | EP | disclosed |