Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.43 |
| ▸ | ESR1 | P03372 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL263798 | 0.97 | ACMSD (0.46) | HDAC4HDAC2HDAC8ACMSDESR2 | |
| SCHEMBL11300109 | 0.97 | HDAC4 (0.44) | HDAC4HDAC2HDAC8ACMSDESR2 | |
| SCHEMBL11555634 | 0.95 | ACMSD (0.44) | HDAC4HDAC2HDAC8ACMSDESR2 | |
| SCHEMBL2029212 | 0.95 | ACMSD (0.44) | HDAC4HDAC2HDAC8ACMSDESR2 | |
| SCHEMBL2031629 | 0.95 | ACMSD (0.44) | HDAC4HDAC2HDAC8ACMSDESR2 | |
| SCHEMBL14184683 | 0.92 | ESR2 (0.47) | HDAC4HDAC2HDAC8ACMSDESR2 | |
| SCHEMBL12297787 | 0.88 | ESR2 (0.48) | ESR2ESR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL778085 | 0.85 | HDAC8 (0.43) | HDAC4HDAC2HDAC8ACMSDESR2 | |
| Phenol SCHEMBL1982027 | 0.85 | KMO (0.47) | HDAC4HDAC2HDAC8ACMSDESR2 | |
| SCHEMBL28797322 | 0.85 | ACMSD (0.39) | HDAC4HDAC2HDAC8ACMSDESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3954889-A | Process for the production of 1,1,3,3-substituted hydroxyindanes | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-04 | — | — | US | claimed |
| US-4370505-A | 1,1,3,3-Substituted hydroxyindanes | BAYER AKTIENGESELLSCHAFT (DE) | 1983-01-25 | — | — | US | disclosed |
| US-4059563-A | ANTIDEGRADATION | NIPPON ZEON CO. LTD. (JA) | 1977-11-22 | — | — | US | disclosed |
| US-4008284-A | ANTIDEGRADATION | NIPPON ZEON CO., LTD. (JA) | 1977-02-15 | — | — | US | disclosed |
| US-3954889-A | Process for the production of 1,1,3,3-substituted hydroxyindanes | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-04 | — | — | US | disclosed |