Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 17/20 | 0.51 |
| ▸ | HSD11B2 | P80365 | 8/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | TACR3 | P29371 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116543 | 0.93 | HSD11B1 (0.60) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1116565 | 0.92 | HSD11B1 (0.51) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1118044 | 0.87 | HSD11B1 (0.45) | HSD11B1HSD11B2 | |
| SCHEMBL1116577 | 0.77 | HSD11B1 (0.43) | HSD11B1HSD11B2 | |
| SCHEMBL704403 | 0.75 | HSD11B1 (0.47) | HSD11B1HSD11B2 | |
| SCHEMBL328942 | 0.75 | HSD11B1 (0.86) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1116567 | 0.75 | HSD11B1 (0.51) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1116636 | 0.74 | HSD11B1 (0.38) | HSD11B1HSD11B2 | |
| SCHEMBL1116561 | 0.74 | HSD11B1 (0.38) | HSD11B1HSD11B2 | |
| SCHEMBL706859 | 0.74 | HSD11B1 (0.46) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280970-B1 | IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2014-01-08 | — | — | EP | disclosed |
| EP-2280970-A1 | IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009132986-A1 | IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-05 | — | — | WO | disclosed |