Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 13/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 10/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 10/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.56 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.56 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11169855 | 0.89 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11161116 | 0.84 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11859273 | 0.84 | ADRA2A (0.68) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11160689 | 0.83 | ADRA2A (0.71) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11161124 | 0.83 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11161260 | 0.83 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11153704 | 0.81 | ADRA2A (0.52) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11161508 | 0.81 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL8022622 | 0.80 | ADRA2A (0.65) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11158573 | 0.80 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0017484-B1 | 2-IMIDAZOLINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION OF THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-04-06 | — | — | EP | disclosed |
| EP-0017484-A1 | 2-Imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-10-15 | — | — | EP | disclosed |