Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 5/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.65 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.65 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.65 |
| ▸ | PTGIR | P43119 | 4/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11162465 | 0.88 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11156792 | 0.85 | ADRA2A (0.56) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11160689 | 0.82 | ADRA2A (0.71) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11161124 | 0.82 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11163652 | 0.80 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11162759 | 0.80 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11166358 | 0.80 | ADRA2A (0.56) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL21497072 | 0.80 | ADRA2A (0.60) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL8020019 | 0.79 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11158573 | 0.79 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971900-A1 | BENZENESULPHONAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPY | SANOFI-SYNTHELABO (FR) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998042679-A1 | BENZENESULPHONAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPY | SANOFI-SYNTHELABO (FR) | 1998-10-01 | — | — | WO | disclosed |
| US-3931216-A | Process for the manufacture of 2-arylamino-2-imidazoline derivatives and their salts | BOEHRINGER INGELHEIM GMBH (DT) | 1976-01-06 | — | — | US | disclosed |